For all the talk about personalized medicine, there’s one ingredient we can all agree is absolutely essential before that can happen: lots and lots of sequence data. But at the current cost of sequencing genomes — just producing a high-quality draft of a mammalian genome costs $25 million, according to the National Human Genome Research Institute — it’s clear it’ll take a long time and a lot of money to accumulate the information required for doctors to prescribe treatments based on an individual’s unique genetic profile.

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The UK's Nuffield Council on Bioethics says genetically modifying human embryos could be morally permissible, according to the Guardian.

A new Nature Biotechnology paper reports that CRISPR-Cas9 gene editing can lead to large deletions or complex rearrangements that could be pathogenic.

The Wall Street Journal likens a prototype developed by Synthetic Genomics to a "biological fax machine."

In PNAS this week: strategy for reactivating Rett syndrome-linked MECP2, small molecules able to suppress Staphylococcus aureus virulence, and more.