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In Silico: Jan 1, 2003

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Gridlock to Grants


A little gridlock can go a long way. The months of political wrangling that created the new US Department of Homeland Security have probably been a good thing, at least from the perspective of the biomedical research community.


Find “New Homeland Security Law Brings Scientific Sigh of Relief” by searching: homeland


What Was That About a Gift Horse?


“I wouldn’t take it if they gave it to me.”

— Craig Venter, referring to Celera’s aging supercomputer


Find “Venter to Bio World: Exa-Byte Me” by searching: firepower


At Least It Wasn’t ‘Ology’


The march of science may be set to the rhythm of language — or at least the sound of whatever comes before “omics.” “How do you define success in science?” asked Jeremy Nicholson at the Imperial College of the University of London. “When I coin my own ‘ome’ word.”


Find “Seeking the Universal Ome” by searching: universal Weekly

Starter Kit


TeleChem/Arrayit has aligned a cartel of companies in an effort to expand a nascent market by giving away a bundle of everything necessary to conduct a microarray experiment. The package includes scanning and image quantification services provided by PerkinElmer and 60 days of GeneTraffic analysis from Iobion.


Find “Giving Away Your Microarray Experiments? Industry Group Hopes It’s Priceless Marketing” by searching: priceless Weekly

Try, Try Again


League of Their Own


“I don’t think we’ve learned how to handle the vendor community properly. We should treat vendor offerings the same as any other in-house project — evaluate benefit, cost, risk, upside, downside — but we don’t actually do that.”

— David Pioli, director of lead discovery informatics at Aventis


Find “Pharma Demands Return on Investment from IT, So How Do You Win Them Over?” by searching: Pioli Weekly

Hall of Mirrors (and Proteins)


When HUPO held court at Versailles, about 880 participants from 34 countries heeded its call to the First World Congress. The program comprised both scientific talks and policy discussions ranging from HUPO initiatives to human proteome efforts around the world, and collaborations between industry and academia.


Find “HUPO Versailles Meeting Showcases the World’s Latest Proteomics Projects” by searching: Versailles

The Scan

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.

Machine Learning Improves Diagnostic Accuracy of Breast Cancer MRI, Study Shows

Combining machine learning with radiologists' interpretations further increased the diagnostic accuracy of MRIs for breast cancer, a Science Translational Medicine paper finds.

Genome Damage in Neurons Triggers Alzheimer's-Linked Inflammation

Neurons harboring increased DNA double-strand breaks activate microglia to lead to neuroinflammation like that seen in Alzheimer's disease, a new Science Advances study finds.

Long COVID-19 Susceptibility Clues Contained in Blood Plasma Proteome

A longitudinal study in eBioMedicine found weeks-long blood plasma proteome shifts after SARS-CoV-2 infection, along with proteomic signatures that appeared to coincide with long Covid risk.