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Sigma and Ingex to Develop Prokaryotic Gene-Disruption System

NEW YORK, Oct. 14 (GenomeWeb News) - Germany-based Sigma-Aldrich and St. Louis, Mo.-based Ingex will collaborate in the development of a "novel" targeted prokaryotic gene-disruption technology, Sigma said yesterday in a statement.


The companies' TargeTron technology involves targeted insertion of a "TargeTron group II" intron into a host genome, resulting in "permanent" target gene knockout into a variety of prokaryotic genomes, said the statement. Targeted insertion is "more than 90 percent successful" and will work "across a broad range" of prokaryotes, the company added.


Future systems are planned for targeted plant and mammalian gene disruption, Sigma said.


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