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Short Reads: Nov 1, 2001 (rev. 1)

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We haven’t heard the last of Rosetta. The company, acquired this spring by Merck, recently announced the formation of Rosetta Biosoftware. The unit will produce and market bioinformatics software products for life sciences research, including new versions of Rosetta Resolver. Doug Bassett was named VP and general manager of the Kirkland, Wash.-headquartered company.

 

It seems spinoffs are all the rage. Caliper Technologies formed Amphora Discovery to build a comprehensive database of chemical genomic information.

 

In a marketing and distribution agreement, Celera Genomics will offer the Structural GenomiX protein structure database with its drug discovery technology suite. SGX also noted that the beamline it funded at Argonne’s Advanced Photon Source should be operational this month.

 

Australia-based Proteome Systems and Germany-based Protagen are working together to study post-translational modifications of proteins.

 

Puffer fish, eat your heart out. It’s zebra fish that’s getting all the attention these days — as shown in the recent multi-year collaboration between Sequitur and Discovery Genomics. The plan is to screen antisense compounds to determine gene function in the organism.

 

Integrative Proteomics and the University of Toronto teamed up to create functional maps of pathogenic bacterial proteomes. Additional funding for the project comes from Genome Canada and the Ontario Research and Development Challenge Fund.

 

The Institute for Systems Biology won a grant for more than $800,000 to continue its protein research. The money will enable the institute to buy mass spectrometers and robotic workstations for preparing and processing protein samples.

 

Bioinformatics company Genomica slashed 100 of 150 jobs shortly before its board of directors passed a shareholders’ rights plan to protect the company against an unwanted takeover attempt.

 

Black death no more? The Sanger Centre was one of several British institutions that participated in sequencing the bacterium responsible for bubonic plague.

 

GeneProt plans to build a high-throughput proteomics laboratory in New Jersey and expects to relocate its headquarters there from its current location in Illinois.

The Scan

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.

Researchers Retrace Key Mutations in Reassorted H1N1 Swine Flu Virus With Avian-Like Features

Mutations in the acidic polymerase-coding gene boost the pathogenicity and transmissibility of Eurasian avian-like H1N1 swine influenza viruses, a PNAS paper finds.

Genome Sequences Reveal Evolutionary History of South America's Canids

An analysis in PNAS of South American canid species' genomes offers a look at their evolutionary history, as well as their relationships and adaptations.

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.