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Sequenom Shares Up 5.5 Percent on Breast Cancer Metastasis Findings

NEW YORK, May 23 (GenomeWeb News) - Shares in Sequenom were up more than 5.5 percent at $.95 in afternoon trading today after the company said its scientists have identified a link between the intracellular adhesion molecule gene ICAM1 and breast cancer metastasis.


According to Sequenom, the researchers found that the level of ICAM1 protein expression in the cell surface positively correlates with metastatic potential of several human breast cancer cell lines, and that ICAM1 mRNA levels were elevated in breast cancer tumor tissue versus normal tissue.


The researchers also found that ICAM1 down-regulation at the mRNA and protein level led to a strong suppression of human breast cell invasion, the company said.


The findings were published in today's issue of Carcinogenesis.

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