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Sequencing Why Did the Chicken Cross the Road? To Be Sequenced, Of Course


Whatever you do, don’t call ’em chicken. This month, Incyte Genomics is scheduled to complete the Chicken Sequencing Project, which it performed under contract for the University of Manchester Institute of Science and Technology, the University of Nottingham, the University of Dundee, and the Roslin Institute. The UK’s Biotechnology and Biological Sciences Research Council is footing the bill for what’s considered the first significant study of avian genomics.

The results should be released at the Chicken Genome Workshop in mid-December. The chicken data, which is owned by the universities, will be made available in public databases.

The project plans to create a genomic database of particular chicken-cell lines that allow individual genes to be manipulated, which in turn might help researchers understand genomic function. “Better knowledge of chicken functional genomics may have a significant impact on the study of retrovirology and embryology,” says William Brown of the University of Nottingham’s Institute of Genetics.

— Kirell Lakhman

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.