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Screening: Yes or No?


The risk of false positives is always a factor in breast cancer screening, but until now there hasn't been any hard data to pin down the exact rate of false positives from mammography. A recent study published in the Annals of Internal Medicine aimed to find out, reports Katherine Hobson at the Wall Street Journal's Health blog. Researchers looked at data from 169,000 women who began breast cancer screening in their 40s or 50s, and analyzed how often women received a biopsy but did not have breast cancer. "About 60 percent of women receiving annual mammograms — whether they began screening in their 40s or 50s — were recalled for additional imaging that showed a normal result over the first ten years of screening," Hobson says. "Some 7 percent of women who began screening in their 40s and 9 percent of women who started in their 50s had a mammographic finding that a biopsy showed to be a false positive." However, the researchers point out that women in their 40s will have a greater cumulative risk of false positive since they'll undergo more mammograms in total in their lives. "The risk of false-positive findings — both after further imaging and after a biopsy — was about a third lower in women who were screened every other year rather than annually," Hobson adds.

The Scan

Shape of Them All

According to BBC News, researchers have developed a protein structure database that includes much of the human proteome.

For Flu and More

The Wall Street Journal reports that several vaccine developers are working on mRNA-based vaccines for influenza.

To Boost Women

China's Ministry of Science and Technology aims to boost the number of female researchers through a new policy, reports the South China Morning Post.

Science Papers Describe Approach to Predict Chemotherapeutic Response, Role of Transcriptional Noise

In Science this week: neural network to predict chemotherapeutic response in cancer patients, and more.