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Scottish Researchers, IBM Team on Supercomputing for HIV Research

NEW YORK (GenomeWeb News) – The University of Edinburgh has entered into a collaboration with the IBM Watson Research Center and the National Physical Laboratory, in Middlesex, to use supercomputers to study surface proteins of HIV-1 with the goal of developing drugs that inhibit HIV infection.
 
The University of Edinburgh said yesterday that knowing the structure and behavior of certain peptides will allow researchers to develop drugs that target the infection process.
 
"This is a new approach to drug design — we are using sophisticated algorithms coupled with experimental techniques to design improved molecular therapies, and we can capitalize on enormous computing power to do this efficiently and rationally," said Jason Crain of Edinburgh’s School of Physics and head of the National Physical Library.

The Scan

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.

DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.

Researchers Model Microbiome Dynamics in Effort to Understand Chronic Human Conditions

Investigators demonstrate in PLOS Computational Biology a computational method for following microbiome dynamics in the absence of longitudinally collected samples.

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.