Skip to main content
Premium Trial:

Request an Annual Quote

Scientists Sequence Genome of Horse Pathogen

NEW YORK, Sept. 21 (GenomeWeb News) - Scientists led by the Institute for Genomic Research have sequenced the genome of Burkholderia mallei, a pathogen that causes the horse disease glanders and has been used as a biological weapon in several wars.


The study, published online last week in PNAS, found that B. mallei, which infects mainly horses, mules, and donkeys but also humans, has a highly regulated set of virulence genes and an unstable genome.


TIGR said it is now examining several other strains and isolates of B. mallei as well as B. pseudomallei under an NIAID microbial sequencing contract.

The Scan

Expanded Genetic Testing Uncovers Hereditary Cancer Risk in Significant Subset of Cancer Patients

In Genome Medicine, researchers found pathogenic or likely pathogenic hereditary cancer risk variants in close to 17 percent of the 17,523 patients profiled with expanded germline genetic testing.

Mitochondrial Replacement Therapy Embryos Appear Largely Normal in Single-Cell 'Omics Analyses

Embryos produced with spindle transfer-based mitochondrial replacement had delayed demethylation, but typical aneuploidy and transcriptome features in a PLOS Biology study.

Cancer Patients Report Quality of Life Benefits for Immune Checkpoint Inhibitors

Immune checkpoint inhibitor immunotherapy was linked in JAMA Network Open to enhanced quality of life compared to other treatment types in cancer patients.

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.