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Scientists Publish Arabidopsis Gene Expression Map as Part of NSF Program

NEW YORK, Dec. 12 (GenomeWeb News) - A $2.2 million gene expression mapping effort - part of the National Science Foundation-funded "Arabidopsis 2010" program - resulted in a Science paper published today that shows where and when 22,000 of the plant's 28,000 genes are activated within growing root tissue.


DukeUniversity scientist Philip Benfey led the collaborative effort with others from New YorkUniversity and the University of Arizona. The researchers said in the Science article that they were able to harvest, lyse, and sort about 10 million cells in one and a half hours. Gene expression localization was analyzed by tracing green fluorescent protein tags that had been introduced into the genes. The tags were followed with ultraviolet light during three successive stages. The data was then "digitally reconstructed" to make a visual map.


The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.