Skip to main content
Premium Trial:

Request an Annual Quote

Scientists Establish Database of Genes Associated With Cancer Drug Resistance

NEW YORK, Aug. 27 (GenomeWeb News) - Scientists at the National Cancer Institute have created a database of information about a group of genes associated with multidrug resistance in cancerous tumors.

 

The database provides details about gene expression of a family of 48 proteins called ABC transporters. The ABC transporters are primarily associated with drug resistance, but in some cases they are associated with an increase in effectiveness of some cancer drugs.

 

"Multidrug resistance is a major barrier to effective cancer chemotherapy, and even low levels of resistance can have a significant impact on the efficacy of chemotherapy," said Gergely Szakacs, the lead author of a paper describing the database that was published in the Aug. 22 issue of Cancer Cell.

 

Szakacs said he and his colleagues hope data in the database will be used to find commonalities in compounds transported by MDR1, one of the ABC proteins most strongly associated with multidrug resistance.

 

Szakacs' paper and information about accessing the gene database can be found online at http://discover.nci.nih.gov/host/2004_cancercell_abstract.jsp.

The Scan

Study Tracks Responses in Patients Pursuing Polygenic Risk Score Profiling

Using interviews, researchers in the European Journal of Human Genetics qualitatively assess individuals' motivations for, and experiences with, direct-to-consumer polygenic risk score testing.

EHR Quality Improvement Study Detects Demographic-Related Deficiencies in Cancer Family History Data

In a retrospective analysis in JAMA Network Open, researchers find that sex, ethnicity, language, and other features coincide with the quality of cancer family history information in a patient's record.

Inflammatory Bowel Disease Linked to Gut Microbiome Community Structure Gradient in Meta-Analysis

Bringing together data from prior studies, researchers in Genome Biology track down microbial taxa and a population structure gradient with ties to ulcerative colitis or Crohn's disease.

Ancient Greek Army Ancestry Highlights Mercenary Role in Historical Migrations

By profiling genomic patterns in 5th century samples from in and around Himera, researchers saw diverse ancestry in Greek army representatives in the region, as they report in PNAS.