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Scientists Establish Database of Genes Associated With Cancer Drug Resistance

NEW YORK, Aug. 27 (GenomeWeb News) - Scientists at the National Cancer Institute have created a database of information about a group of genes associated with multidrug resistance in cancerous tumors.

 

The database provides details about gene expression of a family of 48 proteins called ABC transporters. The ABC transporters are primarily associated with drug resistance, but in some cases they are associated with an increase in effectiveness of some cancer drugs.

 

"Multidrug resistance is a major barrier to effective cancer chemotherapy, and even low levels of resistance can have a significant impact on the efficacy of chemotherapy," said Gergely Szakacs, the lead author of a paper describing the database that was published in the Aug. 22 issue of Cancer Cell.

 

Szakacs said he and his colleagues hope data in the database will be used to find commonalities in compounds transported by MDR1, one of the ABC proteins most strongly associated with multidrug resistance.

 

Szakacs' paper and information about accessing the gene database can be found online at http://discover.nci.nih.gov/host/2004_cancercell_abstract.jsp.