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Saving Mice and the RNA Limit

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By Aaron J. Sender

 

When 30-year National Institute of Mental Health veteran Michael Brownstein first submitted his proposal to study gene expression in mice brains to the institute’s Animal Care and Use Committee, “there was a gasp in the room,” he says. To get just a first pass, low-resolution picture, “I would probably need to kill many hundreds if not thousands of animals,” says Brownstein. “And people said, ‘Gee, isn’t there something you can do about that?’”

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