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SARS Researchers in Canada, China, Singapore Using ProteinChip Technology, Ciphergen Says

This article has been updated to clarify patent filing information in the final paragraph.


NEW YORK, June 3 - Ciphergen said today that researchers at Health Canada's National Microbiology Lab, the Beijing Clinical SARS Testing Center, and the Genomic Institute of Singapore are using its ProteinChip technology to search for novel protein biomarkers associated with Severe Acute Respiratory Syndrome.


Ciphergen said that "a number of potential biomarkers have already been discovered in SARS patient samples" using the company's Expression Difference Mapping protocols on nasopharyngeal, serum, and other samples.


The biomarkers will be further evaluated for use in developing protein-based diagnostic tests for SARS, the company said in a statement, adding that gene-based approaches to diagnosing SARS "currently show significant false negative results."


Ciphergen also said it has collaborated with Health Canada to identify one of the SARS coronavirus proteins by sequencing parts of the protein and determining the mass of protein fragments on a ProteinChip tandem mass spectrometry interface.


Ciphergen has filed for a US patent on the protein.


GenomeWeb Coverage of SARS


Chinese SARS Researchers Use Supercomputers to Characterize Viral Proteins (May 20, 2003)
Abbott Labs Will Help Artus Market, Distribute PCR-based SARS Test (May 15, 2003)

German Group Explores SARS Coronavirus Proteinase Structure (May 13, 2003)

Genome Institute of Singapore Collaborates with Hemispherix on RNA-based SARS Therapeutic (May 13, 2003)

Study Analyzes How SARS Virus Changed As It Spread Across the Globe (May 9, 2003)

InforSense Donates KDE Software to Shanghai for SARS Research (May 8, 2003)

CombiMatrix Develops siRNA to Target SARS Virus (May 7, 2003)

Affymetrix to Offer SARS GeneChip (May 6, 2003)

Focus Tech Claims First RT-PCR SARS Diagnostic (May 5, 2003)

Canadian, US, Chinese Teams Publish SARS Genome Sequence (May 2, 2003)

Roche to Launch RT-PCR-based SARS Diagnostic by July (April 28, 2003)

RNAi Roundup: Qiagen Offers RNAi Expertise to SARS Scientists; Antisense Beats RNAi to SARS Drug Starting Line...(April 25, 2003)

NCID said to Launch PCR Test for SARS Next Week (SNPTech Reporter, April 25, 2003)

CombiMatrix's Ali Arjomand on Developing a SARS Microarray (BioArray News, April 25, 2003)

CombiMatrix to Provide its SARS Arrays Free to Select Governments, Academia (April 23, 2003)

University of Manitoba Proteomics Researchers Tackle SARS Virus Proteins (ProteoMonitor, April 21, 2003)
Beijing Group Publishes Four SARS Sequences from Mainland China, Claims To Have One-Hour SARS Test   (April 21, 2003)

Singapore Team Finishes SARS Virus Genome; Canadian Scientists Identify Viral Proteins  (April 17, 2003)

Singapore Genome Institute Joins SARS Sequencing Fray  (April 16, 2003)

Coronavirus Linked to SARS: WHO (April 16, 2003) 

CombiMatrix Creates Microarray Based on SARS Genome Data   (April 16, 2003)
Canadian Team Leader: SARS Coronavirus Genome Has 11 Novel ORFs   (April 15, 2003)
CDC Hails SARS Virus Sequencing, Discusses PCR Diagnostic Development    (Apr 14, 2003)

CDC Completes SARS Virus Genome Draft On Heels of Canadian Team   (April 14, 2003)

Canadian Team Sequencing SARS Virus   (Apr 9, 2003)
DeRisi Lab Uses its Viral Microarray To Help CDC Zero in on SARS Mystery  (BioArray News, April 4, 2003)

The Scan

Removal Inquiry

The Wall Street Journal reports that US lawmakers are seeking additional information about the request to remove SARS-CoV-2 sequence data from a database run by the National Institutes of Health.

Likely to End in Spring

Free lateral flow testing for SARS-CoV-2 may end in the UK by next spring, the head of Innova Medical Group says, according to the Financial Times.

Searching for More Codes

NPR reports that the US Department of Justice has accused an insurance and a data mining company of fraud.

Genome Biology Papers on GWAS Fine-Mapping Method, COVID-19 Susceptibility, Rheumatoid Arthritis

In Genome Biology this week: integrative fine-mapping approach, analysis of locus linked to COVID-19 susceptibility and severity, and more.