You can't get much better resolution than the single-nucleotide level. Joe Ecker and his team at the Salk Institute report that they've done just that to look at the epigenome of Arabidopsis thaliana. "Our aim was to really go much further — previously, genome-wide analysis of genome methylation of Arabidopsis had used tiling microarrays — and really go to the ultimate resolution of DNA methylation," says Ryan Lister, a postdoc in Ecker's lab and first author on the Cell paper describing their work.

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The US Food and Drug Administration has approved Alnylam's RNAi-based therapy Onpattro, according to Stat News.

Harvard Medical School's Seth Cassel and Cigall Kadoch argue in a Baltimore Sun op-ed that the recent TAILORx trial shows the potential of genomic-based medicine.

Researchers in the UK are working on using gene drives to control malaria-carrying mosquitoes, the Telegraph reports.

In PLOS this week: genetic architecture mediating gene expression, metabolomic patterns in multiple myeloma, and more.