Skip to main content
Premium Trial:

Request an Annual Quote

Roche Taps CDI to Test Candidate Compounds for Cardiotoxicity with Cell-Based Platform

NEW YORK (GenomeWeb News) — Cellular Dynamics International said today it will test drug candidate compounds from Roche Palo Alto for the potential to damage heart tissue.
 
The Madison, Wis.-based CDI said that Roche is providing it with two sets of 25 compounds to test on its platform, which uses human cardiomyocytes derived from human embryonic stem cells. The partners hope to detect any drug-induced changes in the electrical activity of the heart, such as prolongation of the QT interval, which could cause faster, slower, or irregular beating.
 
CDI will also work with Roche on cytotoxicity testing of the compounds in order to build predictive models of toxicology.
 
Nick Seay, CDI’s CTO, said in a statement that the company is focused on developing next-generation models for cardiotoxicity because it is responsible for 30 percent of all drug failures.
 
Chris Kendrick-Parker, CDI’s vice president of business development, said that the validation of the company’s platform through the collaboration is “the first step in using these cells in routine toxicology testing.”
 
Financial terms of the agreement were not released.

The Scan

Ancient Greek Army Ancestry Highlights Mercenary Role in Historical Migrations

By profiling genomic patterns in 5th century samples from in and around Himera, researchers saw diverse ancestry in Greek army representatives in the region, as they report in PNAS.

Estonian Biobank Team Digs into Results Return Strategies, Experiences

Researchers in the European Journal of Human Genetics outline a procedure developed for individual return of results for the population biobank, along with participant experiences conveyed in survey data.

Rare Recessive Disease Insights Found in Individual Genomes

Researchers predict in Genome Medicine cross-population deletions and autosomal recessive disease impacts by analyzing recurrent nonallelic homologous recombination-related deletions.

Genetic Tests Lead to Potential Prognostic Variants in Dutch Children With Dilated Cardiomyopathy

Researchers in Circulation: Genomic and Precision Medicine found that the presence of pathogenic or likely pathogenic variants was linked to increased risk of death and poorer outcomes in children with pediatric dilated cardiomyopathy.