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RNAi Roundup

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This summer, 151 scientists took the time to respond to our RNAi survey and give us a glimpse into the field. The vast majority of respondents say that they’re self-taught, having picked up the technique by reading journal papers. Far more of them are using siRNAs to induce RNAi, but a good number say they’ve at least tried hairpin DNAs. Below, you’ll find results from the survey indicating their experience with RNAi and vendors, as well as what they see as the main hurdles the technology must overcome.

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The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.