Researchers Repress DNA Loop Formation by Applying a Small Force | GenomeWeb

Researchers at the University of Michigan have shown that entropic -forces as small as 100 femtonewtons are capable of altering gene expression. By applying force to DNA tethered to a microscope slide using optical tweezers optimized in their lab, Joshua Milstein says that he and his team were able to effectively slow the rate at which DNA loops were formed by 10-fold.

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