Skip to main content
Premium Trial:

Request an Annual Quote

Researchers Reconstruct Microbial Genomes from Environment

NEW YORK, Feb. 2 (GenomeWeb News) - The University of California, Berkeley said yesterday that university researchers, in collaboration with the Joint Genome Institute, have simultaneously sequenced several genomes from an entire community of microbes.

 

According to the researchers, they were able to reconstruct near-complete genomes of Leptospirillum group II and Ferroplasma type II from a natural acidophilic biofilm using random shotgun DNA sequencing. They added that they were also able to partially recover three other genomes.

 

Their work was detailed this week in the advance online publication of the journal Nature.

 

The researchers stated in the abstract of the Nature article that the biofilm - which was obtained from the floor of an abandoned mine in California - "was dominated by a small number of species populations, and the frequency of genomic rearrangements and gene insertions or deletions was relatively low."

 

They added that "because each sequence read came from a different individual, we could determine that single-nucleotide polymorphisms are the predominant form of heterogeneity at the strain level." Additionally, "analysis of the gene complement for eacch organism revealed the pathways for carbon and nitrogen fixation and energy generation, and provided insights into survival strategies in an extreme environment."

The Scan

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.

Team Presents Cattle Genotype-Tissue Expression Atlas

Using RNA sequences representing thousands of cattle samples, researchers looked at relationships between cattle genotype and tissue expression in Nature Genetics.

Researchers Map Recombination in Khoe-San Population

With whole-genome sequences for dozens of individuals from the Nama population, researchers saw in Genome Biology fine-scale recombination patterns that clustered outside of other populations.

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.