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“No accomplishment by the Department of Energy ranks higher than our historic role in the sequencing of the human genome. Under [Francis Collins’] leadership, the Human Genome Project was finished two and a half years ahead of schedule and 10 percent below the estimated cost. It is just not possible to overstate the difficulty and historical importance of what Francis Collins accomplished. It was Ari — and perhaps it could only have been Ari — who brought together the public and private sector genome programs for a joint announcement on the significant progress the two efforts were making.”

— Excerpted from Secretary of Energy Spencer Abraham’s presention to Francis Collins and Aristides Patrinos last month of the DOE’s highest honor, the Secretary’s Gold Award, for their leadership of the HGP

The Scan

Study Tracks Off-Target Gene Edits Linked to Epigenetic Features

Using machine learning, researchers characterize in BMC Genomics the potential off-target effects of 19 computed or experimentally determined epigenetic features during CRISPR-Cas9 editing.

Coronary Artery Disease Risk Loci, Candidate Genes Identified in GWAS Meta-Analysis

A GWAS in Nature Genetics of nearly 1.4 million coronary artery disease cases and controls focused in on more than 200 candidate causal genes, including the cell motility-related myosin gene MYO9B.

Multiple Sclerosis Contributors Found in Proteome-Wide Association Study

With a combination of genome-wide association and brain proteome data, researchers in the Annals of Clinical and Translational Neurology tracked down dozens of potential multiple sclerosis risk proteins.

Quality Improvement Study Compares Molecular Tumor Boards, Central Consensus Recommendations

With 50 simulated cancer cases, researchers in JAMA Network Open compared molecular tumor board recommendations with central consensus plans at a dozen centers in Japan.