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A Gene, and Treatment Success

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Researchers at St. Jude Children's Research Hospital have found that a mutation in the gene CREBBP could be associated with treatment success in leukemia patients. CREBBP plays an important role in the normal development of blood cells, St. Jude's says. In the study, published in Nature, the researchers found that 18.3 percent of the 71 relapsed leukemia patients they studied carried mutations in CREBBP, compared to only one relapse in the 270 leukemia patients who did not carry the alteration. The mutation is also associated with changes in regulatory regions of the gene that affect cell function, and could be responsible for cancer cells respond to steroid treatments, St. Jude's says.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.