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A Gene, and Treatment Success


Researchers at St. Jude Children's Research Hospital have found that a mutation in the gene CREBBP could be associated with treatment success in leukemia patients. CREBBP plays an important role in the normal development of blood cells, St. Jude's says. In the study, published in Nature, the researchers found that 18.3 percent of the 71 relapsed leukemia patients they studied carried mutations in CREBBP, compared to only one relapse in the 270 leukemia patients who did not carry the alteration. The mutation is also associated with changes in regulatory regions of the gene that affect cell function, and could be responsible for cancer cells respond to steroid treatments, St. Jude's says.

The Scan

And Back

The New York Times reports that missing SARS-CoV-2 genome sequences are back in a different database.

Lacks Family Hires Attorney

A lawyer for the family of Henrietta Lacks plans to seek compensation from pharmaceutical companies that have used her cancer cells in product development, the Baltimore Sun reports.

For the Unknown

The Associated Press reports that family members are calling on the US military to use new DNA analysis techniques to identify unknown sailors and Marines who were on the USS Arizona.

PLOS Papers on Congenital Heart Disease, COVID-19 Infection Host MicroRNAs, Multiple Malformation Mutations

In PLOS this week: new genes linked to congenital heart disease, microRNAs with altered expression in COVID-19, and more.