Driving across the rolling Allegheny Mountains as you make your way from Pittsburgh to Philadelphia, the surprisingly dense, lush stretches of trees might make you wonder if such a rural state could be a hub of any kind. Pennsylvania, however, is not only a leader in biomedical sciences education, but has a thriving biotechnology industrial sector as well. Indeed, the former Quaker State has come a long way since its founding though a land grant to Englishman and Quaker William Penn in 1681.

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In Science this week: International Wheat Genome Sequencing Consortium publishes the bread wheat cultivar Chinese Spring reference genome, and more.

At his FDA Law Blog, Jeffrey Gibbs discusses FDA's technical assistance for the draft Diagnostic Accuracy and Innovation Act.

The New York Times reports that genetic testing has uncovered unfaithful penguins at a Utah aquarium.

Cancer researcher loses funding under new Wellcome Trust anti-bullying policies, the Guardian reports.