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Recent Patents of Interest in Proteomics: Apr 22, 2011

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Recent Patents of Interest in Proteomics

US Patent No. 7,928,367. Methods of preparing samples for MALDI mass spectrometry and reagent compositions for the same. Inventors: Hiroshi Hirota, Miwako Asanuma, Seketsu Fukuzawa, Shigeyuki Yokoyama. Assignee: Riken.

Covers a method of preparing samples for MALDI mass spec by co-crystallizing an analyte and matrix molecule in the presence of porous microparticles in order to inhibit ion suppression by impurities like inorganic salts and surfactants.


US Patent No. 7,927,822. Methods for screening cells and antibodies. Inventors: Christine Genick, Lance Laing, Peter Li, Timothy Smith, Lara Madison, William Karl, Bo Lin. Assignee: SRU Biosystems.

Describes methods of screening many different antibodies in one receptacle and detecting the specific binding of one antibody in a mixture of antibodies to a protein or cell.


US Patent No. 7,927,788. Biomarkers for toxic algae. Inventors: Samuel Lo, Leo Chan, Ivor Hodgkiss. Assignee: The Hong Kong Polytechnic University.

Covers biomarkers including peptide biomarkers that can serve to identify algae specie as well as detect the presence of algal toxins.


US Patent No. 7,927,579. Tandem analyses of noncovalently driven effectors for modulatory mapping of activities of protein sites. Inventors: Alexander Krantz. Assignee: Advanced Proteome Therapeutics.

Covers methods for discovering and mapping secondary binding sites on proteins, the effects of site occupancy on the primary function of the protein, and the screening of small molecules against secondary binding sites.


US Patent No. 7.927,477. Precision flow control system. Inventors: Phillip Paul, Jason Rehm, Don Arnold. Assignee: AB Sciex.

Covers a precision flow controller that can provide a flow rate less than 100 microliters per minute and can vary the flow rate in a predictable and reproducible manner where the accuracy and precision of the flow rate is less than five percent of the flow rate.


US Patent No. 7,923,433. Activity-based probes and methods of their preparation and use. Inventors: David Winn, David Campbell. Assignee: Activx Biosciences.

Describes a method for assessing profiles of catalytically active enzymes in samples containing a plurality of proteins using affinity-based probes that have affinity moieties directing the binding of the ABP to catalytically active target enzymes.


US Patent No. 7,923,254. Method for studying, determining or evaluating pharmacological actions of a test substance on an SART stressed animal. Inventors: Kusuki Nishioka, Tomohiro Kato, Hiroki Fujisawa. Assignee: Nippon Zoki Pharmaceutical.

Covers a method for determining the pharmacological action of a test substance by performing an expression proteome analysis on the brain tissue of a SART (specific alternation of rhythm in temperature) stressed animal treated with the test substance.


US Patent No. 7,921,696. Liquid chromatograph device. Inventors: Kunihiko Takao, Hironori Kaji, Masahito Ito. Assignee: Hitachi High-Technologies.

Covers a liquid feeding system with two pumps in which the first pump operates alone in the starting mode and the second pump operates alone in the normal operating mode.


US Patent No. 7,919,653. Method of inhibiting nonspecific interaction between molecules on solid phase support. Inventors: Akito Tanaka, Tomohiro Terada, Tsuruki Tamura, Takaaki Shiyama, Akira Yamazaki, Minoru Furuya, Masayuki Haramura. Assignee: Reverse Proteomics Research Institute.

Covers a method of suppressing the nonspecific interaction between molecules by regulating the hydrophobic property of a solid phase surface on which the bait molecule is immobilized.


US Patent No. 7,919,261. Methods for predicting treatment response based on the expression profiles of protein and transcription biomarkers. Inventors: Valeria Fantin, Jacqueline Pierce, Andrey Loboda. Assignee: Merck Sharp & Dohme

Covers the use of three proteins whose expression patterns are strongly predictive of a patient's treatment outcome and their use for risk assessment, screening, prognosis and selection, and monitoring of therapy for histone deacetylase-mediated cell proliferation disorders.


US Patent No. 7,915,008. Methods for isolation and analysis of sialylated and phosphorylated peptides. Inventors: Martin Larsen; Assignee: Syddansk University

Describes a technique for detecting biomarkers of conditions associated with a change in sialyation status via titanium dioxide or zirconium dioxide enrichment and mass spec analysis. Also covers specific biomarkers for bladder cancer.


US Patent No. 7,914,792. Methods and compounds for raising antibodies and for screening antibody repertoires. Inventors: Alain Delcayre, Jean-Bernard Le Pecq. Assignee: Exothera.

Covers a method for raising antibodies by providing highly immunogenic vesicles bearing at least one target antigen and immunizing animals with these vesicles. The technique also relates to screening antibody repertoires by providing vesicles bearing at least one target antigen and one marker and isolating antibody-producing cells using these vesicles.


US Patent No. 7,914,656. Matrixes, arrays, systems and methods. Inventors: Shmuel Bukshpan, Gleb Zilbertstein. Assignee: Protein Forest.

Relates to matrixes, arrays, systems, and methods for analyzing biomolecules by their isoelectric point alone and in combination with a second dimension analysis.


US Patent No. 7,910,372. Absolute quantitation of protein contents based on exponentially modified protein abundance index by mass spectrometry. Inventors: Yasushi Ishihama. Assignee: Eisai.

Covers a protein abundance index to determine the protein contents in a protein mixture using nanoLC-MS/MS data.


US Patent No. 7,910,319. Glycoproteomic probes for fluorescent imaging fucosylated glycans in vivo. Inventors: Chi-Huey Wong, Tsui-Ling Hsu, Sarah Hanson, Masaaki Sawa. Assignee: Academia Sinica.

Covers a method of labeling cellular glycans bearing azide groups via a click chemistry fluorescent labeling technique as well as a method of incorporating an azido-containing fucose analog into glycoconjugates via the fucose salvage pathway and a method of visualizing the location of fucosylated glycoconjugates by fluorescence microscopy.

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