People love to complain. Researchers complain about their core labs and core lab workers complain about their users. But how unhappy is everyone, really? Respondents to Genome Technology's fourth core lab survey say they are generally happy with their core labs, consistently awarding them a "good" rating for most metrics. Respondents were particularly pleased with the accuracy of results and the quality of support staff at their cores. Correspondingly, core lab workers said they valued results accuracy and support staff quality in serving their customers.