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Reactome Goes Live, Provides Biological Pathways Data

NEW YORK, June 2 (GenomeWeb News) - Cold Spring Harbor Laboratory and the European Molecular Biology Laboratory today unveiled Reactome, a curated database of biological processes in humans, which is available online at


The database takes a systems-biology approach to pathway analysis, assembling information ranging from the basic processes of metabolism to complex regulatory pathways such as hormonal signaling. Data compiled by biological researchers is managed by curators, and is peer-reviewed by others before being published online, according to a statement by the sponsoring institutions.


Data included in the systems also includes individual biochemical reactions from non-human systems such as rat, mouse, pufferfish, and zebrafish, and must be obtained either via a literature citation or an electronic inference based on sequence similarity.


The Reactome supersedes an earlier project called The Genome Knowledgebase and incorporates all the information previously available there. Also new in Reactome are cross-references to the online databases PubMed, UniProt, LocusLink, Ensembl and the Gene Ontology.


Reactome is an NIH-funded collaboration between Lincoln Stein's laboratory at Cold Spring Harbor Laboratory in New York and the laboratory of Ewan Birney of the European Bioinformatics Institute, part of the European Molecular Biology Laboratory, in Hinxton, UK.


The data in Reactome is free and can be redistributed by both authors and the users, the sponsors said.

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