Potential. That word is the bane of many a student. "Ciara has great potential," said the report cards sent home in elementary school with the trailing "if only she would apply herself" left, perhaps, unwritten. The young investigators in this fourth annual special issue of Genome Technology, however, have put me to shame. They are undaunted by that word "potential" — which they have in spades — and, indeed, have applied themselves to live up to and exceed beyond it.