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With Publication of Chromosome 1, Human Genome Project Closes Final Chapter

NEW YORK, May 17 (GenomeWeb News) - The Wellcome Trust Sanger Institute together with US and British colleagues have published the sequence of human chromosome 1, which is the final chromosome analysis from the Human Genome Project.


The sequence, published in the current Nature, comprises 223.6 million base pairs, and is more than 99.99 percent accurate, according to the report. Gaps in the sequence --- most of which were due to repetitive sequence, according to the report --- comprise around 1.3 million base pairs.


Including the centromere and a large non-coding region in the center of the chromosome, the chromosome is estimated to be 237.6 million base pairs.


The actual sequencing was carried out at the Wellcome Trust Sanger Institute, though the University of Washington Genome Center contributed 13 percent of the sequence finishing. The Wellcome Trust Sanger Institute analyzed the data.


Beside the Wellcome Trust Sanger Institute and the University of Washington Genome Center, participating institutes included the University of Oxford, UK; King's College London; the HUGO Gene Nomenclature Committee; the DukeUniversityCenterfor Human Genetics; and Solexa.

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