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Proteomics Top Challenges For Proteomics


Kicking off the proteomics track at the Beyond Genome conference in late June, Stephen Naylor from MIT’s CSBi program introduced a number of challenges he sees facing proteomics scientists. The good news, he noted, is that proteomics is getting more attention from more researchers, noting that the majority of talks and papers at this year’s ASMS meeting involved proteomics. But there’s some bad news too, he said, including what he called the “graveyard” of embattled or failed proteomics companies.

In a call for better technology and analytical capabilities, Naylor identified proteomics as the current “technology hole” in the systems biology spectrum.

The 10 challenges Naylor identified in proteomics are:

Complex mixture analysis

Differential proteomics

Relative and absolute quantitation

Dynamic range

Membrane proteins

Post-translational modification


Protein arrays and multiplexing

Protein expression and production

Protein informatics

Naylor was not without ideas to conquer these. What’s needed to face these issues, he said, are routine analysis; robustness; reproducibility; sensitivity; specificity; selectivity; speed; and capabilities for stoichiometric quantitation.

— Meredith Salisbury


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