Skip to main content
Premium Trial:

Request an Annual Quote

Proteomics Top Challenges For Proteomics


Kicking off the proteomics track at the Beyond Genome conference in late June, Stephen Naylor from MIT’s CSBi program introduced a number of challenges he sees facing proteomics scientists. The good news, he noted, is that proteomics is getting more attention from more researchers, noting that the majority of talks and papers at this year’s ASMS meeting involved proteomics. But there’s some bad news too, he said, including what he called the “graveyard” of embattled or failed proteomics companies.

In a call for better technology and analytical capabilities, Naylor identified proteomics as the current “technology hole” in the systems biology spectrum.

The 10 challenges Naylor identified in proteomics are:

Complex mixture analysis

Differential proteomics

Relative and absolute quantitation

Dynamic range

Membrane proteins

Post-translational modification


Protein arrays and multiplexing

Protein expression and production

Protein informatics

Naylor was not without ideas to conquer these. What’s needed to face these issues, he said, are routine analysis; robustness; reproducibility; sensitivity; specificity; selectivity; speed; and capabilities for stoichiometric quantitation.

— Meredith Salisbury


The Scan

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.

Circulating Tumor DNA Linked to Post-Treatment Relapse in Breast Cancer

Post-treatment detection of circulating tumor DNA may identify breast cancer patients who are more likely to relapse, a new JCO Precision Oncology study finds.

Genetics Influence Level of Depression Tied to Trauma Exposure, Study Finds

Researchers examine the interplay of trauma, genetics, and major depressive disorder in JAMA Psychiatry.

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.