Skip to main content
Premium Trial:

Request an Annual Quote

ProMetic, Aldevron Expand Collaboration to Develop DNA-Purification Tech

NEW YORK, May 1 - ProMetic BioSciences and Aldevron have expanded their collaboration to develop and market a new product that purifies gene-therapy and DNA-vaccine products, the firms said today.

 

The agreement, which began in 2000, brings together ProMetic's experience designing purification resins with Aldevron's knowledge of plasmid DNA manufacturing, according to the companies.

Aldevron currently uses ProMetic's Perflurosorb S to help it manufacture a West Nile Virus vaccine for the US Center for Disease Control and Prevention. Perflurosorb S is normally used to remove impurities from DNA solutions, said Prometic, which is a Canada-based wholly owned subsidiary of ProMetic Life Sciences.

 

The new collaboration aims at developing Perflurosorb S-based procedures that can be used to produce high-quality DNA for vaccines and gene-therapy applications.

 

"We have demonstrated that Perflurosorb S can be used to ... produce endotoxin-free plasmid DNA, [and] to separate different forms of DNA," said Michael Chambers, president and CEO of Aldevron. "The next step is to design reproducible procedures that can be used for any plasmid-DNA based product. This will represent a significant advancement in gene therapy manufacturing."
 
Through the alliance, Aldevron will develop for ProMetic the DNA purification procedures to be used with the Perflurosorb product line, the companies said. Aldevron will also help ProMetic promote and sell the resin.

 

Click here for more information.

The Scan

Tens of Millions Saved

The Associated Press writes that vaccines against COVID-19 saved an estimated 20 million lives in their first year.

Supersized Bacterium

NPR reports that researchers have found and characterized a bacterium that is visible to the naked eye.

Also Subvariants

Moderna says its bivalent SARS-CoV-2 vaccine leads to a strong immune response against Omicron subvariants, the Wall Street Journal reports.

Science Papers Present Gene-Edited Mouse Models of Liver Cancer, Hürthle Cell Carcinoma Analysis

In Science this week: a collection of mouse models of primary liver cancer, and more.