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Prolexys and Arizona Biodesign Institute Enter Proteomics Collaboration

NEW YORK, April 6 (GenomeWeb News) - Prolexys Pharmaceuticals (formerly Myriad Proteomics) has signed a proteomics-based research collaboration with the Arizona Biodesign Institute at Arizona State University, the company said today.

The researchers will work together to discover peptides and small molecules that modulate vascular tone, with the goal of developing therapies to prevent certain types of stroke as well as the vasodilatory shock associated with hypothermia and sepsis. The project goal is to "produce promising lead candidates within the year," Prolexys said.

The collaboration is based on studies at the Arizona Biodesign Institute involving signal transduction pathways leading to vasorelaxation. Prolexys will use its peptide-based pull-down approach to characterize and isolate interacting proteins in the pathway. These proteins will be used to create assays to screen for modulators of the vasodilation process in smooth muscle, the company said.