Progress in Warfarin Dosing

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Recently, British and Swedish researchers published what they call the first genome-wide association study for warfarin dosing with sufficient power to detect variants of modest effect. In 1,053 Swedish patients, they confirmed the well-known VKORC1 and CYP2C9 SNPs and uncovered a third SNP, CYP4F2, which they then corroborated in an additional cohort of 588 Swedish patients. GT's Ciara Curtin caught up with the Sanger Institute's Panos Deloukas to discuss the implications of his study and what future studies may determine. The team's paper was published in PLoS Genetics.

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