Skip to main content
Premium Trial:

Request an Annual Quote

The Problem with CD24

Premium

A new study published in Cell Stem Cell shows that liver cancers are protected from chemotherapy by a type of "super cancer stem cells" that make the disease resistant to treatment, reports Reuters' Tan Ee Lyn. The stem cells can also spread to other body parts, and can come back even after surgical removal, Lyn says. The stem cells carry the CD24 surface protein, high levels of which lower a patient's chance of survival. CD24 activates the STAT3 protein in cells, which has been shown to form tumors and make them drug resistant. In their experiment, the researchers implanted liver cancers rich in CD24 into mice and found that the cancers became resistant to chemotherapy. They then injected two colonies of liver cancer cells — one with CD24 and one without — into separate parts of the same mouse liver, and found that the part of the liver with the CD24 cells grew cancer that spread to the lungs, and the part of the liver without the CD24 did not, Lyn says. "They went back to human liver cancer patients and found that those with high concentrations of CD24 had a 67 percent chance of cancer recurrence in the first year after surgery, compared to 21 percent recurrence in those with low CD24 count," Lyn adds.

The Scan

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.

Study Reviews Family, Provider Responses to Rapid Whole-Genome Sequencing Follow-up

Investigators identified in the European Journal of Human Genetics variable follow-up practices after rapid whole-genome sequencing.

BMI-Related Variants Show Age-Related Stability in UK Biobank Participants

Researchers followed body mass index variant stability with genomic structural equation modeling and genome-wide association studies of 40- to 72-year olds in PLOS Genetics.

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.