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In Print: Last Week's Microarray Papers of Note: Nov 11, 2014


Rapid screening of peptide probes through in situ single bead sequencing microarray.
Anal Chem. 2014 Nov 5. [Epub ahead of print]
Wang W, et al.

The authors describe a continuous-flow microfluidic method for one-bead-one-compound combinatorial peptide library screening. They screened a peptide bead library within four hours and discovered 140 non-canonical peptide hits targeting the tumor marker aminopeptidase N. They believe the new nanotechnology for peptide screening and identification can "open a new avenue for rapid discovery of new peptide-based reagents for disease diagnostics and therapeutics."

Landscape of DNA methylation on the X chromosome reflects CpG density, functional chromatin state and X-chromosome inactivation.
Hum Mol Genet. 2014 Nov 7. [Epub ahead of print]
Cotton A, et al.

The authors examined the interplay of DNA methylation with CpG density, transcriptional activity, and chromatin state at genes on the X chromosome using over 1,800 female samples analyzed with the Illumina Infinium HumanMethylation450 BeadChip. DNA methylation was used to predict an inactivation status for 63 novel transcription start sites across 27 tissues. The authors believe that their categorization of genes that escape from X inactivation provides candidates for sex-specific differences in disease.

Multiple tumor marker protein chip detection system in diagnosis of pancreatic cancer.
World J Surg Oncol. 2014 Nov 8;12(1):333.
Liu F, et al.

Twelve tumor markers were measured using protein biochips in serum in 235 pancreatic cancer patients, 230 benign pancreatic disease patients, and 240 healthy people. Five markers in particular — CA19-9, NSE, CEA, CA242, and CA125 — were determined to be helpful in the diagnosis of pancreatic cancer.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.