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In Print: Last Week's Microarray Papers of Note: Jul 9, 2013


Familial haplotyping and embryo analysis for Preimplantation Genetic Diagnosis (PGD) using DNA microarrays: a proof of principle study.
J Assist Reprod Genet. 2013 Jul 6. [Epub ahead of print]
Altarescu G, Zeevi D, Zeligson S, et al.

A PGD cycle was performed for a couple with paternal Charcot Marie Tooth 1A using a classic multiplex nested PCR approach. Mutant embryos from the case were blindly reanalyzed using SNP microarrays. After applying a unique informative allele selection algorithm to the data, the array-based assay reconfirmed the initial diagnosis in all samples.

First report of fingerprinting dried herbal products using a subtractive diversity array.
J Complement Integr Med. 2013 Jul 3;10(1):1-11.
Niu L, Mantri N, Wohlmuth H, et al.

The authors report the successful fingerprinting of seven species: Leonurus sibiricus, Astragalus membranaceus, Coix lachryma-jobi, Magnolia biondii, Abutilon theophrasti, Physalis alkekengi, and Salvia miltiorrhiza from dried tissues using a sequence-independent microarray. They claim their technique provides a new way to produce markers for authenticating dried herbal samples.

Neonatal levels of neurotrophic factors and risk of autism spectrum disorders.
Acta Psychiatr Scand. 2013 Jul;128(1):61-9.
Abdallah M, Mortensen E, Greaves-Lord K, et al.

The authors used Luminex assays to examine levels of three neurotrophic factors — brain derived neurotrophic factor, neurotrophin-4, and transforming growth factor-β — in dried blood spot samples of neonates diagnosed with autism spectrum disorders later in life. Results cautiously indicate decreased NTFs levels during neonatal period in ASD.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.