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In Print: Last Week's Microarray Papers of Note: Jul 9, 2013


Familial haplotyping and embryo analysis for Preimplantation Genetic Diagnosis (PGD) using DNA microarrays: a proof of principle study.
J Assist Reprod Genet. 2013 Jul 6. [Epub ahead of print]
Altarescu G, Zeevi D, Zeligson S, et al.

A PGD cycle was performed for a couple with paternal Charcot Marie Tooth 1A using a classic multiplex nested PCR approach. Mutant embryos from the case were blindly reanalyzed using SNP microarrays. After applying a unique informative allele selection algorithm to the data, the array-based assay reconfirmed the initial diagnosis in all samples.

First report of fingerprinting dried herbal products using a subtractive diversity array.
J Complement Integr Med. 2013 Jul 3;10(1):1-11.
Niu L, Mantri N, Wohlmuth H, et al.

The authors report the successful fingerprinting of seven species: Leonurus sibiricus, Astragalus membranaceus, Coix lachryma-jobi, Magnolia biondii, Abutilon theophrasti, Physalis alkekengi, and Salvia miltiorrhiza from dried tissues using a sequence-independent microarray. They claim their technique provides a new way to produce markers for authenticating dried herbal samples.

Neonatal levels of neurotrophic factors and risk of autism spectrum disorders.
Acta Psychiatr Scand. 2013 Jul;128(1):61-9.
Abdallah M, Mortensen E, Greaves-Lord K, et al.

The authors used Luminex assays to examine levels of three neurotrophic factors — brain derived neurotrophic factor, neurotrophin-4, and transforming growth factor-β — in dried blood spot samples of neonates diagnosed with autism spectrum disorders later in life. Results cautiously indicate decreased NTFs levels during neonatal period in ASD.

The Scan

Machine Learning Helps ID Molecular Mechanisms of Pancreatic Islet Beta Cell Subtypes in Type 2 Diabetes

The approach helps overcome limitations of previous studies that had investigated the molecular mechanisms of pancreatic islet beta cells, the authors write in their Nature Genetics paper.

Culture-Based Methods, Shotgun Sequencing Reveal Transmission of Bifidobacterium Strains From Mothers to Infants

In a Nature Communications study, culture-based approaches along with shotgun sequencing give a better picture of the microbial strains transmitted from mothers to infants.

Microbial Communities Can Help Trees Adapt to Changing Climates

Tree seedlings that were inoculated with microbes from dry, warm, or cold sites could better survive drought, heat, and cold stress, according to a study in Science.

A Combination of Genetics and Environment Causes Cleft Lip

In a study published in Nature Communications, researchers investigate what combination of genetic and environmental factors come into play to cause cleft lip/palate.