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In Print: Last Week's Microarray Papers of Note: Jul 9, 2013


Familial haplotyping and embryo analysis for Preimplantation Genetic Diagnosis (PGD) using DNA microarrays: a proof of principle study.
J Assist Reprod Genet. 2013 Jul 6. [Epub ahead of print]
Altarescu G, Zeevi D, Zeligson S, et al.

A PGD cycle was performed for a couple with paternal Charcot Marie Tooth 1A using a classic multiplex nested PCR approach. Mutant embryos from the case were blindly reanalyzed using SNP microarrays. After applying a unique informative allele selection algorithm to the data, the array-based assay reconfirmed the initial diagnosis in all samples.

First report of fingerprinting dried herbal products using a subtractive diversity array.
J Complement Integr Med. 2013 Jul 3;10(1):1-11.
Niu L, Mantri N, Wohlmuth H, et al.

The authors report the successful fingerprinting of seven species: Leonurus sibiricus, Astragalus membranaceus, Coix lachryma-jobi, Magnolia biondii, Abutilon theophrasti, Physalis alkekengi, and Salvia miltiorrhiza from dried tissues using a sequence-independent microarray. They claim their technique provides a new way to produce markers for authenticating dried herbal samples.

Neonatal levels of neurotrophic factors and risk of autism spectrum disorders.
Acta Psychiatr Scand. 2013 Jul;128(1):61-9.
Abdallah M, Mortensen E, Greaves-Lord K, et al.

The authors used Luminex assays to examine levels of three neurotrophic factors — brain derived neurotrophic factor, neurotrophin-4, and transforming growth factor-β — in dried blood spot samples of neonates diagnosed with autism spectrum disorders later in life. Results cautiously indicate decreased NTFs levels during neonatal period in ASD.