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In Print: Last Week's Microarray Papers of Note: Sep 11, 2012


Aberrant expression of long noncoding RNAs in autistic brain.
J Mol Neurosci. 2012 Sep 5. [Epub ahead of print]
Ziats M, Rennert O.

To assess if aberrant expression of long non-coding RNAs may play a role in the molecular pathogenesis of autism spectrum disorder, the authors of this study profiled more than 33,000 annotated lncRNAs and 30,000 mRNA transcripts from postmortem brain tissue of autistic and control prefrontal cortex and cerebellum by microarray.

Women's experiences receiving abnormal prenatal chromosomal microarray testing results.
Genet Med. 2012 Sep 6. [Epub ahead of print]
Bernhardt B, Soucier D, Hanson K, et al.

The authors report that five elements dominated the experiences of women who had received abnormal prenatal microarray results: an offer too good to pass up, blindsided by the results, uncertainty and unquantifiable risks, need for support, and toxic knowledge. They concluded that as prenatal microarray testing is increasingly used, uncertain findings will be common, resulting in greater need for careful pre- and post-test counseling, and more education of and resources for providers so they can adequately support the women who are undergoing testing.

Solid-phase PCR in a picowell array for immobilizing and arraying 100 000 PCR products to a microscope slide.
Lab Chip. 2012 Sep 7;12(17):3049-54.
Hoffmann J, Trotter M, Stetten F, et al.

The authors present a method for performing highly parallel PCR reactions in a picowell array by simultaneously immobilizing generated PCR products in a covalent and spatially-resolved manner onto a microscope slide via solid-phase PCR. The authors claim the technique results in direct spatial registration of immobilized PCR products in a microarray format and will enable the subsequent use for massively parallel analysis similar to standard microarrays (see related story, this issue).

Contribution of global rare copy-number variants to the risk of sporadic congenital heart disease.
Am J Hum Genet. 2012 Sep 7;91(3):489-501.
Soemedi R, Wilson IJ, Bentham J, et al.

The authors generated genome-wide CNV data by using Illumina 660W-Quad SNP arrays in 2,256 individuals with CHD, 283 trio CHD-affected families, and 1,538 controls.

Nupr1-Aurora kinase A pathway provides protection against metabolic stress-mediated autophagic-associated cell death.
Clin Cancer Res. 2012 Sep 7. [Epub ahead of print]
Hamidi T, Cano CE, Grasso D, et al.

Nupr1 expression pattern was analyzed in human tissue microarray and correlated with survival time of the patient. Affymetrix-based transcriptome analysis revealed that Nupr1 knockdown enhances DNA damage and alters the expression of several genes involved in DNA repair and cell-cycle progression.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.