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Princeton Researchers win Stimulus Funds for 'Omics Studies

NEW YORK (GenomeWeb News) – Princeton University researchers will use around $1.8 million in American Recovery and Reinvestment Act funding from the National Institutes of Health and the National Science Foundation to support 'omics-focused studies of antibiotic resistance, cancer, and biological development.

Associate Professor Saeed Tavazoie won $391,000 from NIH to characterize the genetic basis of antibiotic resistance in E. coli bacteria. Tavazoie and his collaborators will explore the role each gene in the E. coli genome plays in its antibiotic resistance, which could lead to information used in developing new drugs and treatments.

Professor Mona Singh will use a $200,000 NIH grant to develop methods and software that can predict protein interactions and to create new analytical techniques to study how proteins interact in a given cell. The studies will focus specifically on zinc finger proteins, which are involved in a number of disease pathways including cancer.

Professor Laura Landweber received an $808,000 grant from NSF to fund studies of mechanisms that bypass traditional modes of genetic inheritance in a single-celled organism called Oxytricha. The aim is to understand an RNA-guided process involved in epigenetics and microbe evolution that could have implications in cancer.

Professor Elizabeth Gavis received a $458,000 NIH grant to fund her work on localizing messenger RNA. The research will involve using genome-wide screens to test whether numerous mRNAs are localized in different cell types in Drosophila. The research may help scientists to understand how localized mRNAs control cellular processes needed for growth and development, and how disruption of these processes could cause diseases.

The Scan

Genes Linked to White-Tailed Jackrabbits' Winter Coat Color Change

Climate change, the researchers noted in Science, may lead to camouflage mismatch and increase predation of white-tailed jackrabbits.

Adenine Base Editor Targets SCID Mutation in New Study

Researchers from the University of California, Los Angeles, report in Cell that adenine base editing was able to produce functional T lymphocytes in a model of severe combined immune deficiency.

Researchers Find Gene Affecting Alkaline Sensitivity in Plants

Researchers from the Chinese Academy of Science have found a locus affecting alkaline-salinity sensitivity, which could aid in efforts to improve crop productivity, as they report in Science.

International Team Proposes Checklist for Returning Genomic Research Results

Researchers in the European Journal of Human Genetics present a checklist to guide the return of genomic research results to study participants.