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Personalized Medicine Guilford Initiative Gears up with $2.2M DOD Funding

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The promise of personalized medicine has been long heralded, to be sure, but a program in central North Carolina is taking steps to transform the talk into clinical reality.

The Guilford Genomic Medicine Initiative is a collaborative effort bringing together about 30 people at three partner institutions: the Moses Cone Health System, the Duke University Center for Human Genetics, and the University of North Carolina at Greensboro. “We’re really working as a partnership,” says Vincent Henrich, director of the Institute for Health, Science and Society at UNC Greensboro. “There’s a lot of communication going on, and I think that’s been essential for us in terms of making this really move forward.”

Also moving the project forward is funding from the latest defense appropriations bill to the tune of $2.2 million dollars. Three years ago, the project kicked off with initial defense funding in the amount of $3.4 million.

It was a confluence of ideas that sparked the GGMI about six years ago, recalls Margaret Pericak-Vance, director of the Duke University Center for Human Genetics. It was then that Pericak-Vance and her husband, Jeffery Vance — a neurologist, medical geneticist, and associate director of the center — started talking about setting up a model to incorporate the latest findings in genomics with clinical care. Around that time, Patricia Sullivan, chancellor at UNC Greensboro and Pericak-Vance’s old biology prof, was setting up the state’s first and only genetic counseling graduate program. Pericak-Vance saw the synergy at once and signed Sullivan on to the project. As she tells it, “[UNC Greensboro] has the genetic counseling school, the excellent education, and we have the informatics and genomics background. We’re both interested in personalized or genomic medicine, so the idea was to take all of our expertise and put them together.”

Henrich leads the project’s educational core, which is committed to developing programs designed to teach healthcare workers and members of the community about what it means to bring genomics to the bedside. He says the project’s goal is to “educate the physicians, the community, the patients about genomic medicine to the point where they feel comfortable and informed enough to have a dialogue.”

Another component, Henrich says, is “working with the community health system, which we’re doing with the Moses Cone Healthcare Center.” That center provides primary clinical sites and administers the program’s DOD funding and subcontracting to partner institutions.

Although the program is initially looking at genetic risk factors associated with thrombosis as well as breast and ovarian cancers, Pericak-Vance stresses that “the diseases themselves are instruments for us to see how to develop a model” for clinical practice. One of the applications for the GGMI model will be the US military healthcare system, says Henrich.

— Jen Crebs

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