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Perlegen, Women s Health Initiative to Study SNPs Linked to Hormone Tx, Disease

NEW YORK, June 30 (GenomeWeb News) - Perlegen Sciences will help the Women's Health Initiative identify SNPs related to a trio of diseases linked to the use of postmenopausal hormone therapy, the company said today.


With funding from the National Heart, Lung and Blood Institute, WHI will work with Perlegen to conduct a comparative whole-genome study of SNPs in patients with coronary heart disease, stroke, or breast cancer versus controls.

 

Perlegen will genotype the SNPs initially in selected cases and controls from the Observational Study arm of the WHI study. These results will be preliminarily validated in a separate set of cases and controls from that OS cohort, while a "final" validation and replication will focus on the interactions of the disease-associated SNPs with the combined estrogen plus progestin therapy in samples from the randomized controlled clinical trial cohort, Perlegen said.

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