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Perlegen Wins $13.2M NIH Grant to Map DNA of Certain Mouse Strains

NEW YORK, Oct. 26 (GenomeWeb News) - The National Institute of Environmental Health Services has awarded $13.2 million to Perlegen to map the DNA of 15 mouse strains believed to be important to human research, the company said yesterday.

 

The 2-year funding will pay for approximately 55 percent of the project, Perlegen said. The remainder of the funding, approximately $10.8 million, will be provided by unidentified non-government sources.

 

The initiative, dubbed the "Resequencing Project," will launch the NIEHS' Center for Rodent Genetics. The center joins other NIEHS initiatives, such as the Environmental Genome Project and the National Center for Toxicogenomics, as "extensions of the institute's ongoing research to understand the genetic basis for differences in response to drugs and other environmental factors," NIEHS said in a statement.

 

Perlegen will use Affymetrix's whole-wafer, high-density oligonucleotide arrays to analyze the approximately 2.4-billion-base-pair genomes in order to identify SNPs and other genetic differences, Perlegen said. Perlegen is a spin-off of Affymetrix.

The Scan

Interfering With Invasive Mussels

The Chicago Tribune reports that researchers are studying whether RNA interference- or CRISPR-based approaches can combat invasive freshwater mussels.

Participation Analysis

A new study finds that women tend to participate less at scientific meetings but that some changes can lead to increased involvement, the Guardian reports.

Right Whales' Decline

A research study plans to use genetic analysis to gain insight into population decline among North American right whales, according to CBC.

Science Papers Tie Rare Mutations to Short Stature, Immunodeficiency; Present Single-Cell Transcriptomics Map

In Science this week: pair of mutations in one gene uncovered in brothers with short stature and immunodeficiency, and more.