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Perlegen and RIKEN Partner on 47-Disease Genomic Association Study

NEW YORK, July 21 (GenomeWeb News) - As part of a collaboration agreement, Perlegen subsidiary Perlegen Sciences Japan and the Japanese Institute of Physical and Chemical Research, or RIKEN, will conduct genomic association studies to find the causes of 47 common diseases, the organizations said yesterday in a statement.


The collaboration will involve analysis of more than 250,000 SNPs in samples collected as part of the BioBank Japan initiative coordinated by the University of Tokyo's Institute of Medical Science, which includes 66 hospitals across the country, the statement said. At present, the collection includes DNA and clinical data from about 150,000 patients.


Perlegen will use "next-generation" Affymetrix technology in first-pass genome scanning, while RIKEN's SNPResearchCenter will conduct fine mapping in candidate regions associated with disease, and will conduct follow-up research on promising genomic regions, the statement said.


Initial studies will focus on cancer and heart disease, but the project will eventually also include atherosclerosis, rheumatoid arthritis, epilepsy, heart failure, chronic obstructive pulmonary disease, asthma, arrhythmia, cerebral infarction, and several cancers, the partners said.


Funding for the project will be provided by the Japanese Ministry of Education, Culture, Sports, Science, and Technology, said Brad Margus, Perlegen's CEO.

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