In mid-May, Genome Technology hunkered down with four high-performance computing experts to continue its IT solutions roundtable series. After going through cost issues in the last discussion, this conversation focused on performance questions. What’s the real secret to optimizing your infrastructure? During the hour-long event, our gurus examined HPC from clock speed to ASICs to the interaction of biologists with computer scientists. As you’ll see from the following excerpts, they didn’t need much prodding from GT staff to get the debate going.