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Pennsylvania Bucks

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Pennsylvania researchers rake in $1.4 billion through NIH grant funding, making them one of the top-funded states in the nation. (You’d think with a place called “Bucks County” they wouldn’t need money, but it seems that is not the case.) Plenty of that funding goes toward various efforts in systems biology. To compile this chart, GT sorted through the grants to find ones clearly related to the disciplines under the systems biology umbrella, and for the sake of space, selected the institutes with the most funding. This list, current as of April, is not comprehensive.

 

Award PI Name Project Title

CARNEGIE-MELLON UNIVERSITY

$667,733
Alan Waggoner
Long Wavelength Quantum Dot-based Probes — Cell Tracking

CHILDREN''S HOSPITAL OF PHILADELPHIA

$3,891,453
Robert Levy
Genetic Mechanisms in Pediatric Heart Disease

$2,045,913
Michael Phillips
Cellular and Molecular Biology of Lipoprotein Metabolism

$1,464,576
Katherine High
Gene Therapy for Hemophilia

$620,632
John Wolfe
Gene Transfer and NMR Studies in Alpha-mannosidosis Brain

FOX CHASE CANCER CENTER

$710,395
Jose Russo
Genomic Basis of Reproductive History on Breast Cancer

INSTITUTE FOR CANCER RESEARCH

$570,610
Melvin Bosma
Control of Ig Gene Expression in Ig Transgenic Mice

$490,935
Christoph Seeger
Functional Analysis of the Hepatitis C Virus Genome

PENNSYLVANIA STATE UNIVERSITY

$878,630
Webb Miller
Software for Analyzing Biosequence Data

TEMPLE UNIVERSITY

$1,137,262
Shohreh Amini
Signal Pathways Modulating HIV-1-induced Injury in CNS

$499,217
Keith Latham
Primate Embryo Gene Expression Resource

THOMAS JEFFERSON UNIVERSITY

$4,358,919
Renato Baserga
Translational Research in Cancer

$1,194,918
Walter Curran
Relevance of Genomic Alterations in Colorectal Cancer

$617,526
Paolo Fortina
Four Color Array Bound SNP/Mutation Detection in Cancer

$518,486
David Strayer
SFV Gene Delivery to Inhibit HIV and SIV Integrase

UNIVERSITY OF PENNSYLVANIA

$2,566,982
Raquel Gur
The Neurobiology of Stimulus Encoding in Schizophrenia

$2,227,380
Garret Fitzgerald
Signal Transduction in Atherosclerosis

$1,993,142
Klaus Kaestner
Functional Genomics of the Beta-Cell

$1,868,203
James Wilson
DNA Virus as Vectors for Cardiovascular Diseases

$1,304,368
Steven Albelda
Gene Therapy for Malignant Mesothelioma

$1,292,648
Virginia Lee
Tauopathies: Genotype and Phenotype

$1,221,960
Alan Gewirtz
Examing Oligonucleotide Effects on Gene Expression

$792,224
Arlen Price
Fine Localization of Genes for Human Obesity

$771,572
Ian Blair
Fourier Transform Mass Spec Proteomics and Genomics

$670,000
Richard Spielman
Genome-wide Analysis of Genetic Variation Expression

$629,123
Christian Stoeckert
Plasmodium Genome Database

$613,221
William Degrado
Proteomics to Biomimetic Polymers: Engineering Principle

$612,152
Alexander Whitehead
Pharmacogenetics of Methotrexate Therapy in Arthritis

$503,153
Lyle Ungar
Training Grant in Computational Genomics

$501,437
Raquel Gur
The Genetics of Endophenotypes and Schizophrenia

$501,047
Arlen Price
Genetic Studies of Obesity

$470,122
James Alwine
Regulation of Cellular Functions by DNA Tumor Viruses

$457,333
Michael Nusbaum
Graduate Training in Systems and Integrative Biology

UNIVERSITY OF PITTSBURGH

$3,449,355
Joseph Glorioso
Cardiovascular Gene Therapy Center

$1,474,970
Joseph Glorioso
Gene and Cell Therapy of Duchenne Muscular Dystrophy

$734,599
Cynthia Gadd
Pittsburgh Biomedical Informatics Training Program

$646,005
Joseph Zmuda
Bone Strength Phenotypes in Men: Genes and Environment

$613,075
Daniel Shaw
Pathways to Early-and Late-Starting Antisocial Behavior

$479,208
William Bigbee
Serum Proteomic Biomarkers for Colon & Pancreatic Cancer

WISTAR INSTITUTE

$602,469
David Speicher
Novel Comprehensive Proteome Analyses of Metastasis

 

The Scan

Study Tracks Responses in Patients Pursuing Polygenic Risk Score Profiling

Using interviews, researchers in the European Journal of Human Genetics qualitatively assess individuals' motivations for, and experiences with, direct-to-consumer polygenic risk score testing.

EHR Quality Improvement Study Detects Demographic-Related Deficiencies in Cancer Family History Data

In a retrospective analysis in JAMA Network Open, researchers find that sex, ethnicity, language, and other features coincide with the quality of cancer family history information in a patient's record.

Inflammatory Bowel Disease Linked to Gut Microbiome Community Structure Gradient in Meta-Analysis

Bringing together data from prior studies, researchers in Genome Biology track down microbial taxa and a population structure gradient with ties to ulcerative colitis or Crohn's disease.

Ancient Greek Army Ancestry Highlights Mercenary Role in Historical Migrations

By profiling genomic patterns in 5th century samples from in and around Himera, researchers saw diverse ancestry in Greek army representatives in the region, as they report in PNAS.