NEW YORK, May 15 - Paradigm Genetics has been issued a patent in the United States for "Methods and Materials for the Rapid and High Volume Production of a Gene Knock-Out Library in an Organism."
The patent, No. 6,562,624, covers Paradigm's Transposon-Arrayed Gene Knock-Out technology, which according to the company provides methods "for the rapid and systematic mutation of pathogenic fungi." These methods are designed to enable researchers to identify antifungal and fungicide targets, as well as biosynthetic and degradation pathways, Paradigm said.
To date, Paradigm has won two Notices of Allowance from the US Patent and Trademark Office for fungicide target patent applications. They are: "Methods for the Identification of Inhibitors of 5-Aminolevulinate Synthase as Antibiotics" and "Methods for the Identification of Inhibitors of Threonine Synthase as Antibiotics."