An Open Secret

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One of the most widely known instances of scientific ghostwriting involves Wyeth, the medical-writing company DesignWrite, and the hormone replacement drugs Premarin and Prempro. According to documents that PLoS and the New York Times sued to make available to the public, and which are now housed on a website at the University of California, San Francisco, DesignWrite and Wyeth developed research and review articles that portrayed hormone replacement therapies in a positive light.

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