NEW YORK, April 29 - Third Wave Technologies' manufacturing divisions will be hardest hit as the company starts cutting 25 percent of its workforce in a broader effort to cut costs.

Third Wave, which announced the staff reductions last week, had a headcount of roughly 300 people at the end of 2001. A spokesman said that while the lay offs were "across the board," they do not forecast a departure from genomics research and that all of its product development activities will continue.

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