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Number Crunch: Feb 1, 2001

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Recent data from Paolo P. Saviotti, Marie Angele de Looze, Sylvie Michelland, and David Catherine show the growth and spread of bioinformatics firms.

Tech Fields Using Bioinformatics

PHARMACEUTICALS 21%

GENOMICS 12%

AGRICULTURE 11%

BIOLOGICALS 7%

DIAGNOSTICS 6%

CHEMICALS 5%

ENVIRONMENTAL 2%

Other 34%

Bioinformatics Startups, 1961 - 1998

Year /Specialized Firms /Non specialized firms /Total Creation firms

1961 0 1 1
1967 0 1 1
1971 1 0 1
1978 1 0 1
1979 0 1 1
1981 1 1 2
1982 1 1 2
1983 1 0 1
1984 2 1 3
1985 1 0 1
1986 0 2 2
1988 0 1 1
1989 2 4 6
1990 2 2 4
1991 2 1 3
1992 2 6 8
1993 9 5 14
1994 3 5 8
1995 7 1 8
1996 6 3 9
1997 14 11 25
1998 17 6 23

Where Are the Bioinformatics Companies?

Belgium 2%
Canada 3%
Germany 16%
France 5%
Netherlands 1%
Sweden 1%
UK 7%
US 62%
Israel 1%

The Scan

Drug Response Variants May Be Distinct in Somatic, Germline Samples

Based on variants from across 21 drug response genes, researchers in The Pharmacogenomics Journal suspect that tumor-only DNA sequences may miss drug response clues found in the germline.

Breast Cancer Risk Gene Candidates Found by Multi-Ancestry Low-Frequency Variant Analysis

Researchers narrowed in on new and known risk gene candidates with variant profiles for almost 83,500 individuals with breast cancer and 59,199 unaffected controls in Genome Medicine.

Health-Related Quality of Life Gets Boost After Microbiome-Based Treatment for Recurrent C. Diff

A secondary analysis of Phase 3 clinical trial data in JAMA Network Open suggests an investigational oral microbiome-based drug may lead to enhanced quality of life measures.

Study Follows Consequences of Early Confirmatory Trials for Accelerated Approval Indications

Time to traditional approval or withdrawal was shorter when confirmatory trials started prior to accelerated approval, though overall regulatory outcomes remained similar, a JAMA study finds.