Skip to main content
Premium Trial:

Request an Annual Quote

Novel NCI, LeadScope Informatics Platform Marries Data From Gene Expression and Cancer Drugs

NEW YORK, Aug. 22 - The National Cancer Institute and informatics company LeadScope have built a bioinformatics tool that links gene-expression data with information about antiangiogenic compounds, the organizations said today.


"Someone who is trying to design or perfect cancer drugs would ideally like to relate a gene or protein directly to drug structure," John Weinstein, an NCI scientist, said in a statement. The purpose of the bioinformatics is to explain how the chemical nature of drugs affects behavior in various cell lines, he added.


This drug-design and -discovery tool, outlined in the August issue of The Pharmacogenomics Journal, uses LeadScope and LeadMiner software to tie together a pair databases of information about cells and chemical compounds: The first includes inhibition information gleaned from about 80,000 chemical compounds and 60 human cancer cell lines known as NCI-60, and the second contains gene-expression patterns for those cells lines, according to Columbus, Ohio-based LeadScope.


Click here for more information.

The Scan

Cell Signaling Pathway Identified as Metastasis Suppressor

A new study in Nature homes in on the STING pathway as a suppressor of metastasis in a mouse model of lung cancer.

Using Bees to Gain Insights into Urban Microbiomes

As bees buzz around, they pick up debris that provides insight into the metagenome of their surroundings, researchers report in Environmental Microbiome.

Age, Genetic Risk Tied to Blood Lipid Changes in New Study

A study appearing in JAMA Network Open suggests strategies to address high lipid levels should focus on individuals with high genetic risk and at specific ages.

Study Examines Insights Gained by Adjunct Trio RNA Sequencing in Complex Pediatric Disease Cases

Researchers in AJHG explore the diagnostic utility of adding parent-child RNA-seq to genome sequencing in dozens of families with complex, undiagnosed genetic disease.