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Not so Fast, Leukemia

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Investigators at Weill Cornell Medical College and their colleagues at the University of California, San Francisco, have discovered the reason why acute lymphoblastic leukemia cells survive powerful cancer drugs, according to a UCSF press release. As described in the team's study, published in Nature, the researchers found that leukemia cells use a protein called BCL6 to stay alive, and say that targeting the protein may be the key to fighting drug-resistant leukemia. The researchers showed that when mice with drug-resistant leukemia were treated with conventional drugs in combination with a BCL6-supressor — a compound called RI-BPI, developed by Weill Cornell's Ari Melnick — they were cured of the disease, UCSF says.

The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.