Investigators at Weill Cornell Medical College and their colleagues at the University of California, San Francisco, have discovered the reason why acute lymphoblastic leukemia cells survive powerful cancer drugs, according to a UCSF press release. As described in the team's study, published in Nature, the researchers found that leukemia cells use a protein called BCL6 to stay alive, and say that targeting the protein may be the key to fighting drug-resistant leukemia. The researchers showed that when mice with drug-resistant leukemia were treated with conventional drugs in combination with a BCL6-supressor — a compound called RI-BPI, developed by Weill Cornell's Ari Melnick — they were cured of the disease, UCSF says.
Not so Fast, Leukemia
May 24, 2011