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Not so Fast, Leukemia


Investigators at Weill Cornell Medical College and their colleagues at the University of California, San Francisco, have discovered the reason why acute lymphoblastic leukemia cells survive powerful cancer drugs, according to a UCSF press release. As described in the team's study, published in Nature, the researchers found that leukemia cells use a protein called BCL6 to stay alive, and say that targeting the protein may be the key to fighting drug-resistant leukemia. The researchers showed that when mice with drug-resistant leukemia were treated with conventional drugs in combination with a BCL6-supressor — a compound called RI-BPI, developed by Weill Cornell's Ari Melnick — they were cured of the disease, UCSF says.

The Scan

Gap in COVAX Doses

BBC News reports that COVAX is experiencing a vaccine shortfall, as the Serum Institute of India has paused exports.

Sanofi, GSK Report Promising Results

The Wall Street Journal reports that the candidate SARS-CoV-2 vaccine from Sanofi and GlaxoSmithKline has had encouraging early results.

Influence of Luck

The New York Times examines how the US avoided variant-fueled increases in COVID-19 cases.

PLOS Papers on Retina GWAS, Hantaan Virus, COVID-19 Phenome-Wide Association Study

In PLOS this week: genome-wide association study of retinal morphology, analysis of hantaan virus found in a mouse, and more.