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NINR Providing $2M to Fund Genomics Studies for Chronic Wound Repair

By a GenomeWeb staff reporter
NEW YORK (GenomeWeb News) – The National Institute of Nursing Research wants to use recent advances in genomic medicine to develop new applications for handling patients with chronic wounds, and plans to about $2 million to fund up to eight new projects to pursue that goal.

In a new request for applications, NINR said it plans to fund studies that will increase knowledge about the genomic mechanisms linked to the repair of chronic wounds, how to identify individuals who are at highest risk for developing them, and to enable the development of customized therapeutics and interventions that are tailored to an individual's genomic profile.

The institute plans to provide up to $275,000 per year for the two-year grants.

A range of research approaches have shown promise in this area, NINR points out.
Recent advances have made it possible to identify genes involved in chronic wound development and repair, and candidate genes have revealed SNPs that could be used as indicators of specific types of ulcers. Also, gene expression studies have shown differential expression of genes involved with inflammation and repair over the course of wound healing, and human and animal studies have demonstrated the roles of epigenetic mechanisms and non-coding RNAs in wound healing.

"While these and other findings have shown great potential for using genomic information to assess the risk for developing chronic wounds as well to facilitate the healing process, ongoing research is needed to search for additional genomic markers, to characterize the functional properties of genomic variants, and to successfully combine genomic and non-genomic information to inform the search for effective treatments,"
NINR said in the RFA.

Investigators pursuing these grants could propose a number of types of projects, including, but not limited to elucidating genomic markers and mechanisms related to wound susceptibility, development, progression, and repair, such as identifying SNPS, CNVs, and non-coding genomic species; the investigation of epigenomic modifications, and determination of the effects of variants and epigenomic modifications on gene expression; and the development of strategies that incorporate genomic information with contributing factors, such as age, environment, and others.

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