Skip to main content
Premium Trial:

Request an Annual Quote

NIH Sets Aside New $100K-$500K SBIR Grants for RNAi Research

NEW YORK, Jan. 31 (GenomeWeb News) - The National Institutes of Health will be awarding grants to members of the small business community to support efforts that "develop new approaches and chemical modifications that will increase the long term stability, delivery, and targeting of siRNAs in cells and tissues for laboratory and therapeutic applications," the NIH said last week.

 

Budgets up to $100,000 per year, and time periods up to two years for Phase I programs, may be requested, the NIH noted. Budgets up to $500,000 per year, and up to three years, may be requested for Phase II programs.

 

According to the NIH, "the need to combine high specificity with high potency is important to the continued development of siRNA in research and therapy development." As such, the award program "will focus on techniques and technologies leading to improved chemical synthesis and delivery of RNAi, particularly those incorporating chemical modifications that change the properties of the siRNA molecules to increase their stability and their ability to be delivered more efficiently to target cells without increasing their toxicity."

 

The awards will be made under the Small Business Innovation Research and Small Business Technology Transfer mechanisms, the NIH said. The number of awards will depend on the merits of the applications and the availability of funds.

 

Additional details about the funding opportunities are available here.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.