NEW YORK, Oct. 25 (GenomeWeb News) - The US National Institutes of Health issued last week an RFA requesting research proposals related to membrane protein production and structure determination.
Under the RFA program, the NIH plans to commit about $5 million during 2005. The number of projects receiving funding will depend on the number of requests made.
According to the NIH, National Institute of General Medical Sciences is accepting applications for a program funding the "development of innovative methods for production of membrane proteins, production of proteins in sufficient quantities for study, and structural studies of membrane proteins."
According to the NIH, researchers' "understanding of the structure, function, and mechanisms of integral membrane proteins has been limited by the paucity of available high resolution structures."
As a result, the institute is looking for project proposals involving "novel approaches to cloning, expression, oligomeric assembly, solubilization, stabilization, and purification of membrane proteins [that will] advance the production of structurally and functionally intact membrane proteins suitable for structural studies." The agency is also looking for innovative "methods for structure determination, including crystallization, phasing, isotopic labeling, and collection of x-ray crystallographic, nuclear magnetic resonance, and other relevant data," the RFA said.
Proposals for projects designed to "obtain preliminary data in support of regular investigator-initiated research projects and to conduct structural studies of integral membrane proteins" are also being accepted.
Letters of intent for those seeking funding are due by Dec. 23. Applications are due by